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The aim of the present study was to evaluate the effects of implant materials such as dense hydroxyapatite, porous replamineform hydroxyapatite, polymeric reinforced zinc-oxide eugenol in the treatment of furcation involvement area of dogs. Experimental furcation defects created in the mandibular 2nd, 3rd, 4th premolar of 8 dogs. Bone was surgically removed from the furcation area and stainless steel wires were passed through the furcations and ligated. After 6 weeks, the wires were removed, and regenerative procedures were performed in experimental areas divided into 5 groups. The 5 groups were as follows 1) no treatment (Untreated control group) 2) flap operation (Treated control group) 3) flap operation with hydroxyapatite implant (HA group) 4) flap operation with replamineform hydroxyapatite implant (RHA group) 5) flap operation with polymeric reinforced zinc-oxide eugenol implant (IRM group) At 2,4,8.12 week. dogs were serially sacrificed and the specimens were prepared with hematoxylin and eosin stain for the light microscopic finding. The results were as follows ; 1. In the RHA group. osteoid tissue formation around the implant material was observed at 2 week, and bony density and amount was increased in the course of experimental periods. 2. In the HA particles were surrounded by dense connective tissue, while IRM group, severe inflammatory cell infiltration in the connective tissue was observed at 12 week. 3. Highly activated osteoblast on the interradicular bone was observed in all groups except IRM group at 2 week. but it decreased gradually. 4. The degree of inflammotory cell infiltration was decreased in the course of time in the HA, RHA and treated control group compared with that of IRM and untreated control group. 5. The epithelial migration was observed during whole experimental periods in all groups. 6. At 12 week, connective tissue fibers in periodontal ligament space were not arranged functionally in the experimental groups.
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